Neuroanatomical substrates of visual hallucinations in patients with non-demented Parkinson's disease
Identifieur interne : 000031 ( Main/Exploration ); précédent : 000030; suivant : 000032Neuroanatomical substrates of visual hallucinations in patients with non-demented Parkinson's disease
Auteurs : Soojeong Shin [Corée du Sud] ; Ji Eun Lee [Corée du Sud, Niger] ; Jin Yong Hong [Corée du Sud] ; Mun-Kyung Sunwoo [Corée du Sud] ; Young Ho Sohn [Corée du Sud] ; Phil Hyu Lee [Corée du Sud, Niger]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2012-12.
Abstract
Background Visual hallucinations (VH), which are common in patients with Parkinson's disease (PD), lead to increased disability and are a significant predictor of the development of dementia. However, the neuroanatomical basis for VH in non-demented PD patients remains controversial. Methods A total of 110 patients with PD were classified into PD with VH (n=46) and PD without VH (n=64) groups, depending on the presence of VH assessed by the caregiver-based structured interview of the Neuropsychiatric Inventory. We performed voxel-based morphometry (VBM) for grey matter (GM) volume and a region-of-interest-based volumetric analysis of the substantia innominata (SI) between two groups. Results The comprehensive neuropsychological assessment showed that PD patients with VH showed more severe cognitive deficits in delayed visual memory and frontal executive functions compared with those without VH. A VBM analysis revealed that PD patients with VH had significantly lower GM volume in the right orbitofrontal, left temporal and left thalamic areas compared with those without VH. The normalised SI volume was significantly reduced in PD patients with VH compared with those without VH (1.28±0.22 vs 1.41±0.25, p=0.005). Conclusions The present study demonstrates that non-demented PD patients with VH exhibited a smaller volume in the frontal, temporal and thalamic areas as well as the SI, suggesting that PD hallucinators may have distinctive neuroanatomical bases relative to PD non-hallucinators.
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DOI: 10.1136/jnnp-2012-303391
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However, the neuroanatomical basis for VH in non-demented PD patients remains controversial. Methods A total of 110 patients with PD were classified into PD with VH (n=46) and PD without VH (n=64) groups, depending on the presence of VH assessed by the caregiver-based structured interview of the Neuropsychiatric Inventory. We performed voxel-based morphometry (VBM) for grey matter (GM) volume and a region-of-interest-based volumetric analysis of the substantia innominata (SI) between two groups. Results The comprehensive neuropsychological assessment showed that PD patients with VH showed more severe cognitive deficits in delayed visual memory and frontal executive functions compared with those without VH. A VBM analysis revealed that PD patients with VH had significantly lower GM volume in the right orbitofrontal, left temporal and left thalamic areas compared with those without VH. The normalised SI volume was significantly reduced in PD patients with VH compared with those without VH (1.28±0.22 vs 1.41±0.25, p=0.005). Conclusions The present study demonstrates that non-demented PD patients with VH exhibited a smaller volume in the frontal, temporal and thalamic areas as well as the SI, suggesting that PD hallucinators may have distinctive neuroanatomical bases relative to PD non-hallucinators.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Niger</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Shin, Soojeong" sort="Shin, Soojeong" uniqKey="Shin S" first="Soojeong" last="Shin">Soojeong Shin</name></noRegion><name sortKey="Hong, Jin Yong" sort="Hong, Jin Yong" uniqKey="Hong J" first="Jin Yong" last="Hong">Jin Yong Hong</name><name sortKey="Lee, Ji Eun" sort="Lee, Ji Eun" uniqKey="Lee J" first="Ji Eun" last="Lee">Ji Eun Lee</name><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><name sortKey="Sohn, Young Ho" sort="Sohn, Young Ho" uniqKey="Sohn Y" first="Young Ho" last="Sohn">Young Ho Sohn</name><name sortKey="Sunwoo, Mun Kyung" sort="Sunwoo, Mun Kyung" uniqKey="Sunwoo M" first="Mun-Kyung" last="Sunwoo">Mun-Kyung Sunwoo</name></country><country name="Niger"><noRegion><name sortKey="Lee, Ji Eun" sort="Lee, Ji Eun" uniqKey="Lee J" first="Ji Eun" last="Lee">Ji Eun Lee</name></noRegion><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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